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Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication

6 Apr 2023

Abstract excerpt

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent for the global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived replication organelles, including double-membrane vesicles (DMVs), in the host cell to support viral replication. Here, we clarify how SARS-CoV-2 hijacks host factors to construct the DMVs. We show that the ER morphogenic proteins...

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PMID: 37093123
DOI: 10.1083/jcb.202203060

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