A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.

doi:10.1093/eurheartj/ehx174

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Article

A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.

European heart journal - 14 Jun 2017

Coassin Stefan, Erhart Gertraud, Weissensteiner Hansi, Eca Guimarães de Araújo Mariana, Lamina Claudia, Schönherr Sebastian, Forer Lukas, Haun Margot, Losso Jamie Lee, Köttgen Anna, Schmidt Konrad, Utermann Gerd, Peters Annette, Gieger Christian, Strauch Konstantin, Finkenstedt Armin, Bale Reto, Zoller Heinz, Paulweber Bernhard, Eckardt Kai-Uwe, Hüttenhofer Alexander, Huber Lukas A, Kronenberg Florian

Abstract excerpt

AIMS: Lp(a) concentrations represent a major cardiovascular risk factor and are almost entirely controlled by one single locus (LPA). However, many genetic factors in LPA governing the enormous variance of Lp(a) levels are still unknown. Since up to 70% of the LPA coding sequence are located in a difficult to access hypervariable copy number variation named KIV-2, we hypothesized that it may contain novel...

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PMID: 28444229
DOI: 10.1093/eurheartj/ehx174
PMCID: PMC5837733

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