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Article

Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease.

Journal of the American College of Cardiology - 3 Aug 2021

Schachtl-Riess Johanna F, Kheirkhah Azin, Grüneis Rebecca, Di Maio Silvia, Schoenherr Sebastian, Streiter Gertraud, Losso Jamie Lee, Paulweber Bernhard, Eckardt Kai-Uwe, Köttgen Anna, Lamina Claudia, Kronenberg Florian, Coassin Stefan

Abstract excerpt

BACKGROUND: Lipoprotein(a) (Lp(a)) concentrations are a major independent risk factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up to 70% of the LPA coding sequence is located in the hypervariable kringle IV type 2 (KIV-2) region. It is hardly accessible by conventional technologies, but may contain functional variants. OBJECTIVES: This study sought to investigate the new,...

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Identifiers

PMID: 34325833
DOI: 10.1016/j.jacc.2021.05.037
PMCID: PMC7613585

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