Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes.

Abstract excerpt

The kinetoplast incorporates the large mitochondrial genome present in the eponymous Kinetoplastida. Trypanosoma brucei is an African trypanosome that can lose kinetoplast DNA (kDNA), however, when the nuclear-encoded gamma subunit of the mitochondrial F1FO-ATP synthase (γATPase) is mutated. These mutations, analogous to a broken camshaft at the core of the ATP synthase rotary motor, are associated with multidrug...

Topics

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• DNA, Kinetoplast
• Mitochondria
• Mitochondrial Proton-Translocating ATPases
• Mutation
• Proteome