Article
Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.
The Journal of infectious diseases - 1 Dec 2012
Grant Audrey V, Alter Andrea, Huong Nguyen Thu, Orlova Marianna, Van Thuc Nguyen, Ba Nguyen Ngoc, Thai Vu Hong, Abel Laurent, Schurr Erwin, Alcais Alexandre
Abstract excerpt
A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2,...
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