Article
Actionable Mutation Profile of Sun-Protected Melanomas in South America.
The American Journal of dermatopathology - 1 Oct 2022
Hsieh Ricardo, Nico Marcello M S, Camillo Cláudia M C, Oliveira Kátia K, Carraro Dirce M, Sangueza Martin, Lourenço Silvia V
Abstract excerpt
ABSTRACT: Melanomas that arise in sun-protected sites, including acral and oral mucosal melanomas, are likely under the control of unique, specific mechanisms that lead to mutagenesis through various pathways. In this study, we examined somatic mutations in tumors by targeted sequencing using a custom Ion Ampliseq Panel, comprising hotspots of 14 genes that are frequently mutated in solid tumors. Tumor DNA was...
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