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Article

Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma.

Pigment cell & melanoma research - 1 Nov 2013

Dutton-Regester Ken, Kakavand Hojabr, Aoude Lauren G, Stark Mitchell S, Gartside Michael G, Johansson Peter, O'Connor Linda, Lanagan Cathy, Tembe Varsha, Pupo Gulietta M, Haydu Lauren E, Schmidt Christopher W, Mann Graham J, Thompson John F, Scolyer Richard A, Hayward Nicholas K

Abstract excerpt

Melanoma of unknown primary (MUP) is an uncommon phenomenon whereby patients present with metastatic disease without an evident primary site. To determine their likely site of origin, we combined exome sequencing from 33 MUPs to assess the total rate of somatic mutations and degree of UV mutagenesis. An independent cohort of 91 archival MUPs was also screened for 46 hot spot mutations highly prevalent in melanoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23890154
DOI: 10.1111/pcmr.12153

Genes

BRAF
NRAS
GNA11
GNAQ
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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