Article
Ultraviolet radiation drives mutations in a subset of mucosal melanomas.
Nature communications - 11 Jan 2021
Mundra Piyushkumar A, Dhomen Nathalie, Rodrigues Manuel, Mikkelsen Lauge Hjorth, Cassoux Nathalie, Brooks Kelly, Valpione Sara, Reis-Filho Jorge S, Heegaard Steffen, Stern Marc-Henri, Roman-Roman Sergio, Marais Richard
Abstract excerpt
Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal...
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