Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.

American journal of physiology. Endocrinology and metabolism - 1 Feb 2008

Aigner Bernhard, Rathkolb Birgit, Herbach Nadja, Hrabé de Angelis Martin, Wanke Rüdiger, Wolf Eckhard

Abstract excerpt

More than 150 million people suffer from diabetes mellitus worldwide, and this number is expected to rise substantially within the next decades. Despite its high prevalence, the pathogenesis of diabetes mellitus is not completely understood. Therefore, appropriate experimental models are essential tools to gain more insight into the genetics and pathogenesis of the disease. Here, we describe the current efforts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethylnitrosourea

Share to Genetic Testing

Share to Hyperglycemia

Share to Mutagenesis

Share to Mutagens

Source

Identifiers

PMID: 18056790
DOI: 10.1152/ajpendo.00592.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.PMID 18056790Read ↗

A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.Semantic proximity Read ↗

Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants.Semantic proximity Read ↗

Criteria for creating and assessing mouse models of diabetic neuropathy.Semantic proximity Read ↗

A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.Semantic proximity Read ↗

Transgenic and Knockout Mice in Diabetes Research: Novel Insights into Pathophysiology, Limitations, and PerspectivesSemantic proximity Read ↗

Genetic and Pharmacologic Models for Type 1 DiabetesSemantic proximity Read ↗

Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).Semantic proximity Read ↗

Mouse models created to study the pathophysiology of Type 2 diabetesSemantic proximity Read ↗

Mice with targeted gene disruptions or gene insertions for diabetes research: problems, pitfalls, and potential solutionsSemantic proximity Read ↗

Features and strategies of ENU mouse mutagenesis.Semantic proximity Read ↗

A Review of Mouse Models of Monogenic Diabetes and ER Stress Signaling.Semantic proximity Read ↗

NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.