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Article

A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility.

Genome research - 1 Dec 2010

Tan Iris K L, Mackin Leanne, Wang Nancy, Papenfuss Anthony T, Elso Colleen M, Ashton Michelle P, Quirk Fiona, Phipson Belinda, Bahlo Melanie, Speed Terence P, Smyth Gordon K, Morahan Grant, Brodnicki Thomas C

Abstract excerpt

More than 25 loci have been linked to type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse, but identification of the underlying genes remains challenging. We describe here the positional cloning of a T1D susceptibility locus, Idd11, located on mouse chromosome 4. Sequence analysis of a series of congenic NOD mouse strains over a critical 6.9-kb interval in these mice and in 25 inbred strains identified...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21051460
DOI: 10.1101/gr.101881.109
PMCID: PMC2989989

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Source receipt: pubmed, retrieved 7 Sept 2026.

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