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Article

RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs

1 Feb 2019

Abstract excerpt

Abstract To unravel molecular mechanisms by which Runt-related transcription factor 1 (RUNX1) mutations contribute to leukemic transformation, we introduced the RUNX1-S291fs300X mutation in human CD34+ stem/progenitor cells and in human induced pluripotent stem cells (iPSCs). In both models, RUNX1mut overexpression strongly impaired myeloid commitment. Instead, self-renewal was enhanced, as shown, by increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30709863
DOI: 10.1182/bloodadvances.2018024422

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