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Article

RUNX1 cooperates with FLT3-ITD to induce leukemia

17 Feb 2017

Abstract excerpt

Acute myeloid leukemia (AML) is induced by the cooperative action of deregulated genes that perturb self-renewal, proliferation, and differentiation. Internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase are common mutations in AML, confer poor prognosis, and stimulate myeloproliferation. AML patient samples with FLT3-ITD express high levels of RUNX1, a transcription factor with known...

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PMID: 28213513
DOI: 10.1084/jem.20160927

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