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Article

Incorporating local ancestry improves identification of ancestry-associated methylation signatures and meQTLs in African Americans.

Communications biology - 29 Apr 2022

Li Boyang, Aouizerat Bradley E, Cheng Youshu, Anastos Kathryn, Justice Amy C, Zhao Hongyu, Xu Ke

Abstract excerpt

Here we report three epigenome-wide association studies (EWAS) of DNA methylation on self-reported race, global genetic ancestry, and local genetic ancestry in admixed Americans from three sets of samples, including internal and external replications (Ntotal= 1224). Our EWAS on local ancestry (LA) identified the largest number of ancestry-associated DNA methylation sites and also featured the highest replication...

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Black or African American
Black People
DNA Methylation
Polymorphism, Single Nucleotide
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35488087
DOI: 10.1038/s42003-022-03353-5
PMCID: PMC9054854

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