Article
Genome-wide methylation data mirror ancestry information.
Epigenetics & chromatin - 1 Jan 2017
Rahmani Elior, Shenhav Liat, Schweiger Regev, Yousefi Paul, Huen Karen, Eskenazi Brenda, Eng Celeste, Huntsman Scott, Hu Donglei, Galanter Joshua, Oh Sam S, Waldenberger Melanie, Strauch Konstantin, Grallert Harald, Meitinger Thomas, Gieger Christian, Holland Nina, Burchard Esteban G, Zaitlen Noah, Halperin Eran
Abstract excerpt
BACKGROUND: Genetic data are known to harbor information about human demographics, and genotyping data are commonly used for capturing ancestry information by leveraging genome-wide differences between populations. In contrast, it is not clear to what extent population structure is captured by whole-genome DNA methylation data. RESULTS: We demonstrate, using three large-cohort 450K methylation array data sets,...
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