Article

Genetic ancestry-specific meQTLs control immune function regulation in a breast cancer cohort of African and European patients

2024-08-30

Abstract excerpt

We explored the impact of genetic ancestry on DNA methylation (DNAm) in African and European ancestry breast cancer patients. Analyzing data from 578 subjects in The Cancer Genome Atlas (TCGA) cohort, we identified 757 differentially methylated sites associated with genetic ancestry (aDMS). Methylation quantitative trait loci (meQTL) mapping showed that the majority of aDMS are regulated by multiple SNPs different...

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Literature Corpus work: 69620409-ac82-56a6-9f68-d080ca6c34fe
DOI: 10.1101/2024.08.29.610316

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