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Article

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors.

Oncoimmunology - 1 Jan 2022

Hackett Justin B, Glassbrook James E, Muñiz Maria C, Bross Madeline, Fielder Abigail, Dyson Gregory, Movahhedin Nasrin, McCasland Jennifer, McCarthy-Leo Claire, Gibson Heather M

Abstract excerpt

Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic background influences response. To investigate this, we utilized the Diversity Outbred (DO) and Collaborative Cross (CC) mouse models. DO mice are an outbred stock...

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Identifiers

PMID: 35481286
DOI: 10.1080/2162402X.2022.2064958
PMCID: PMC9037414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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