Article

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans

2024-07-16

Abstract excerpt

Identifying host genetic factors modulating immune checkpoint inhibitor (ICI) efficacy has been experimentally challenging because of variations in both host and tumor genomes, differences in the microbiome, and patient life exposures. Utilizing the Collaborative Cross (CC) multi-parent mouse genetic resource population, we developed an approach that fixes the tumor genomic configuration while varying host genetic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65e3b25a-a6a9-576f-a17d-b2f35eb62429
DOI: 10.1101/2024.07.11.603136

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humansDOI 10.1101/2024.07.11.603136Read

A Diversity Outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitorsSemantic proximity Read

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors.Semantic proximity Read

A susceptibility gene signature for ERBB2-driven mammary tumor development and metastasis in Collaborative Cross mice with human translational valueSemantic proximity Read

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative CrossSemantic proximity Read

Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.Semantic proximity Read

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.Semantic proximity Read

A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.Semantic proximity Read

The genetics of cancer susceptibility: from mouse to man.Semantic proximity Read

Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross miceSemantic proximity Read

Adaptive immune response to West Nile virus infection in the Collaborative Cross mouse model: A database of cellular phenotypes and Quantitative Trait Loci.Semantic proximity Read

Genetically distinct microenvironment determines cancer survival and response to therapy in miceSemantic proximity Read

Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.Semantic proximity Read