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Host genetic background regulates the capacity for anti-tumor antibody-dependent phagocytosis

2023-05-09

Abstract excerpt

<h4>Background</h4> Antitumor antibody, or targeted immunotherapy, has revolutionized cancer treatment and markedly improved patient outcomes. A prime example is the monoclonal antibody (mAb) trastuzumab, which targets human epidermal growth factor receptor 2 (HER2). However, like many targeted immunotherapies, only a subset of patients benefit from trastuzumab long-term. In addition to tumor-intrinsic factors, w...

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Literature Corpus work
446bedb7-882b-57c2-b6de-d596ccfecec8
DOI
10.1101/2023.05.09.540046
Open publication

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Host genetic background regulates the capacity for anti-tumor antibody-dependent phagocytosisDOI 10.1101/2023.05.09.540046
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