Article
Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise.
Genome research - 1 Jun 2013
Dadiani Maya, van Dijk David, Segal Barak, Field Yair, Ben-Artzi Gil, Raveh-Sadka Tali, Levo Michal, Kaplow Irene, Weinberger Adina, Segal Eran
Abstract excerpt
Individual cells from a genetically identical population exhibit substantial variation in gene expression. A significant part of this variation is due to noise in the process of transcription that is intrinsic to each gene, and is determined by factors such as the rate with which the promoter transitions between transcriptionally active and inactive states, and the number of transcripts produced during the active...
Topics
- Binding Sites
- Cluster Analysis
- Gene Expression Profiling
- Gene Expression Regulation
- Genetic Variation
- Poly A-U
- Promoter Regions, Genetic
- Protein Binding
- Reproducibility of Results
- Transcription Factors