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E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors

1 Sept 2019

Abstract excerpt

The human genome is constantly exposed to both endogenous and exogenous stresses, which can lead to errors in DNA replication and the accumulation of DNA mutations, thereby increasing the risk of cancer development. The transcription factor E2F1 is a key regulator of DNA repair. E2F1 also has defined roles in the replication of many cell cycle-related genes and is highly expressed in cancer cells, and its...

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PMID: 31534120
DOI: 10.1038/s12276-019-0307-2

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