Article
HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status.
Arthritis research & therapy - 25 Apr 2022
Sharma Seema, Plant Darren, Bowes John, Macgregor Alex, Verstappen Suzanne, Barton Anne, Viatte Sebastien
Abstract excerpt
BACKGROUND: Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are associated with radiological outcome, anti-TNF response and all cause-mortality in RA. RA is associated with cardiovascular (CV) morbidity and mortality, but the increased prevalence of risk factors of CV disease in RA only partially explains this association. The aim...
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