Article
Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative Rheumatoid Arthritis Study.
American journal of epidemiology - 15 Jul 2017
Birru Talabi Mehret, Mackey Rachel H, Kuller Lewis H, Dorman Janice S, Deane Kevin D, Robinson William H, Walitt Brian T, Chang Yuefang, Holers V Michael, Liu Simin, Moreland Larry W
Abstract excerpt
Specific alleles of the human leukocyte antigen (HLA)-DRB1 gene (HLA-DRB1) encode a "shared epitope" (SE) associated with rheumatoid arthritis (RA), especially more severe cyclic-citrullinated peptide antibody-positive (anti-CCP+) RA. We evaluated associations of number of SE alleles (0, 1, or 2) with total and cardiovascular disease (CVD) mortality and incident coronary heart disease (CHD), CVD, and cancer over...
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