Article
Associations of HLA-DRB1 shared epitope alleles with cardiovascular disease and events in a multi-ethnic community-living population: The multi-ethnic study of atherosclerosis (MESA).
Human immunology - 1 May 2025
Kaur Manmeet, Katz Ronit, Criqui Michael H, Corr Maripat, Post Wendy S, Budoff Matthew, Morris Gerald P, Hughes-Austin Jan M
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) has been considered an independent risk factor for cardiovascular disease (CVD), where RA and CVD later manifest following genetic predisposition and an extended preclinical phase.TheHLA-DRB1Shared Epitope (SE)allelespredispose for RA andare associated withhigherrisk of CV mortality in RA patients, but have not been evaluated in a community-living population.Thus, we evaluated...
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