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Article

Genome-Wide Assessment of Shared Genetic Architecture Between Rheumatoid Arthritis and Cardiovascular Diseases.

Journal of the American Heart Association - 21 Nov 2023

Guo Yanjun, Chung Wonil, Shan Zhilei, Zhu Zhaozhong, Costenbader Karen H, Liang Liming

Abstract excerpt

BACKGROUND: Patients with rheumatoid arthritis (RA) have a 2- to 10-fold increased risk of cardiovascular disease (CVD), but the biological mechanisms and existence of causality underlying such associations remain to be investigated. We aimed to investigate the genetic associations and underlying mechanisms between RA and CVD by leveraging large-scale genomic data and genetic cross-trait analytic approaches....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37947095
DOI: 10.1161/JAHA.123.030211
PMCID: PMC10727280

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