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Article

Standardizing the CAP Score in Huntington’s Disease by Predicting Age-at-Onset

19 Apr 2022

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is an autosomal dominant, neurological disease caused by an expanded CAG repeat near the N-terminus of the huntingtin (HTT) gene. A leading theory concerning the etiology of HD is that both onset and progression are driven by cumulative exposure to the effects of mutant (or CAG expanded) huntingtin (mHTT). The CAG-Age-Product (CAP) score (i.e., the product of excess CAG...

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PMID: 35466943
DOI: 10.3233/jhd-210475

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