The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease.

Abstract excerpt

Huntington disease (HD) is caused by an expanded HTT CAG repeat that leads in a length-dependent, completely dominant manner to onset of a characteristic movement disorder. HD also displays early mortality, so we tested whether the expanded CAG repeat exerts a dominant influence on age at death and on the duration of clinical disease. We found that, as with clinical onset, HD age at death is determined by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age Factors
• Share to Aged, 80 and over