Article
Clinical and genetic characteristics of late-onset Huntington's disease in a large European cohort.
European journal of neurology - 1 Jul 2022
Petracca Martina, Di Tella Sonia, Solito Marcella, Zinzi Paola, Lo Monaco Maria Rita, Di Lazzaro Giulia, Calabresi Paolo, Silveri Maria Caterina, Bentivoglio Anna Rita
Abstract excerpt
BACKGROUND AND PURPOSE: Huntington's disease (HD) is an autosomal dominant condition caused by CAG-triplet repeat expansions. CAG-triplet repeat expansion is inversely correlated with age of onset in HD and largely determines the clinical features. The aim of this study was to examine the phenotypic and genotypic correlates of late-onset HD (LoHD) and to determine whether LoHD is a more benign expression of HD....
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