Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Longer CAG repeat length is associated with shorter survival after disease onset in Huntington disease.

American journal of human genetics - 6 Jan 2022

Langbehn Douglas R

Abstract excerpt

It is well known that the length of the CAG trinucleotide expansion of the huntingtin gene is associated with many aspects of Huntington disease progression. These include age of clinical onset and rate of initial progression of disease severity. The relationship between CAG length and survival in Huntington disease is less studied. To address this, we obtained the complete Registry HD database from the European...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Genetic Neurodegenerative Diseases
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Mortality

Share to Proportional Hazards Models

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 34942093
DOI: 10.1016/j.ajhg.2021.12.002
PMCID: PMC8764269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Longer CAG repeat length is associated with shorter survival after disease onset in Huntington disease.PMID 34942093Read ↗

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG lengthSemantic proximity Read ↗

The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease.Semantic proximity Read ↗

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.Semantic proximity Read ↗

Statistical modeling of Huntington disease onset.Semantic proximity Read ↗

Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats.Semantic proximity Read ↗

Association of CAG Repeats With Long-term Progression in Huntington DiseaseSemantic proximity Read ↗

Influence of Age of Onset on Huntington's Disease Phenotype.Semantic proximity Read ↗

Clinical and genetic characteristics of late-onset Huntington's disease in a large European cohort.Semantic proximity Read ↗

Huntington's disease: clinical correlates of disability and progression.Semantic proximity Read ↗

Standardizing the CAP Score in Huntington’s Disease by Predicting Age-at-OnsetSemantic proximity Read ↗

Characterization of a large group of individuals with huntington disease and their relatives enrolled in the COHORT study.Semantic proximity Read ↗

The Clinical Features and Progression of Late-Onset Versus Younger-Onset in an Adult Cohort of Huntington's Disease Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.