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Article

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length

12 Mar 2004

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by an unstable CAG repeat. For patients at risk, participating in predictive testing and learning of having CAG expansion, a major unanswered question shifts from "Will I get HD?" to "When will it manifest?" Using the largest cohort of HD patients analyzed to date (2913 individuals from 40 centers worldwide), we developed a parametric survival model...

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PMID: 15025718
DOI: 10.1111/j.1399-0004.2004.00241.x

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