The Clinical Features and Progression of Late-Onset Versus Younger-Onset in an Adult Cohort of Huntington's Disease Patients.

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that typically manifests between the ages of 30 and 50 years. However, the disease can present at any age, and phenotypic differences between younger and later-onset patients have received limited attention. OBJECTIVE: To compare clinical features of late- (>70 years of age) and younger-onset (<30 years of age) HD patients....

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