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Comparison of the Clinical Spectrum of Juvenile- and Adult-Onset Huntington Disease

22 Apr 2025

Abstract excerpt

BACKGROUND AND OBJECTIVES: Differences in clinical characteristics between juvenile-onset Huntington disease (JHD) and adult-onset HD (AHD) are hypothesized but not directly compared. This study compares clinical characteristics occurrence and severity across age-at-onset (AO) subtypes. METHODS: Using the national juvenile-onset HD patient cohort and the international Enroll-HD registry (NCT01574053), we compared...

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PMID: 40262071
DOI: 10.1212/wnl.0000000000213525

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