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Article

Association of CAG Repeats With Long-term Progression in Huntington Disease

12 Aug 2019

Abstract excerpt

IMPORTANCE: In Huntington disease (HD), mutation severity is defined by the length of the CAG trinucleotide sequence, a well-known predictor of clinical onset age. The association with disease trajectory is less well characterized. Quantifiable summary measures of trajectory applicable over decades of early disease progression are lacking. An accurate model of the age-CAG association with early progression is...

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Identifiers

PMID: 31403680
DOI: 10.1001/jamaneurol.2019.2368

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