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Article

Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.

EMBO reports - 1 Sept 2001

Mittler G, Kremmer E, Timmers H T, Meisterernst M

Abstract excerpt

Human Mediator complexes have been described as important bridging factors that enhance the effect of activators in purified systems and in chromatin. Here we report a novel basal function of a human Mediator complex. A monoclonal antibody was generated that depleted the majority of Mediator components from crude cell extracts. The removal of human Mediator abolished transcription by RNA polymerase II. This was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11559591
DOI: 10.1093/embo-reports/kve186
PMCID: PMC1084041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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