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Article

Glycometabolic reprogramming-mediated proangiogenic phenotype enhancement of cancer-associated fibroblasts in oral squamous cell carcinoma: role of PGC-1α/PFKFB3 axis.

British journal of cancer - 1 Aug 2022

Li Xiang, Jiang Erhui, Zhao Hui, Chen Yang, Xu Yuming, Feng Chunyu, Li Ji, Shang Zhengjun

Abstract excerpt

BACKGROUND: Angiogenesis is a key rate-limiting step in the process of tumour progression. Cancer-associated fibroblasts (CAFs), the most abundant component OSCC stroma, play important roles in pro-angiogenesis. Recently, the stroma "reverse Warburg effect" was proposed, and PFKFB3 has been brought to the forefront as a metabolic enzyme regulating glycometabolism. However, it remains unclear whether...

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Source

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Identifiers

PMID: 35444287
DOI: 10.1038/s41416-022-01818-2
PMCID: PMC9345921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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