Article
BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy.
Nature communications - 19 Nov 2022
McGrail Kimberley, Granado-Martínez Paula, Esteve-Puig Rosaura, García-Ortega Sara, Ding Yuxin, Sánchez-Redondo Sara, Ferrer Berta, Hernandez-Losa Javier, Canals Francesc, Manzano Anna, Navarro-Sabaté Aura, Bartrons Ramón, Yanes Oscar, Pérez-Alea Mileidys, Muñoz-Couselo Eva, Garcia-Patos Vicenç, Recio Juan A
Abstract excerpt
NRAS-mutated melanoma lacks a specific line of treatment. Metabolic reprogramming is considered a novel target to control cancer; however, NRAS-oncogene contribution to this cancer hallmark is mostly unknown. Here, we show that NRASQ61-mutated melanomas specific metabolic settings mediate cell sensitivity to sorafenib upon metabolic stress. Mechanistically, these cells are dependent on glucose metabolism, in...
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