Article

The glycolysis regulator PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma

2020-03-24

Abstract excerpt

Cell migration is a complex process, tightly regulated during embryonic development and abnormally activated during cancer metastasis. RAS-dependent signaling is a major nexus controlling essential cell parameters including proliferation, survival and migration, utilizing downstream effectors such as the PI3K/AKT signaling pathway. In melanoma, oncogenic mutations frequently enhance RAS, PI3K/AKT or MAP kinase sig...

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Literature Corpus work: d7d8eb11-9894-5d6c-bf82-a3baaa2a5295
DOI: 10.1101/2020.03.23.004119

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