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Unraveling the intricacies of cancer‐associated fibroblasts: a comprehensive review on metabolic reprogramming and tumor microenvironment crosstalk

14 Jun 2024

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are crucial component of tumor microenvironment (TME) which undergo significant phenotypic changes and metabolic reprogramming, profoundly impacting tumor growth. This review delves into CAF plasticity, diverse origins, and the molecular mechanisms driving their continuous activation. Emphasis is placed on the intricate bidirectional crosstalk between CAFs and tumor cells,...

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PMID: 38873945
DOI: 10.1111/apm.13447

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