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Article

Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.

World journal of surgical oncology - 28 Mar 2023

Cheng Xiao, Jia Xiupeng, Wang Chunnian, Zhou Shangyan, Chen Jiayi, Chen Lei, Chen Jinping

Abstract excerpt

BACKGROUND: Breast cancer is the most common tumor in women worldwide. Diabetes mellitus is a global chronic metabolic disease with increasing incidence. Diabetes mellitus has been reported to positively regulate the development of many tumors. However, the specific mechanism of hyperglycemic environment regulating breast cancer remains unclear. PFKFB3 (6-phosphofructose-2-kinase/fructose-2, 6-bisphosphatase 3)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36973739
DOI: 10.1186/s12957-023-02990-2
PMCID: PMC10044395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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