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Article

Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.

Cell death & disease - 18 Apr 2022

Hou Mingying, Shao Zhengbo, Zhang Shiqi, Liu Xinna, Fan Pan, Jiang Menglu, Zhao Yutong, Xiao Rong, Yuan Huiping

Abstract excerpt

Retinal ganglion cells (RGCs) axons are the signal carriers of visual information between retina and brain. Therefore, they play one of the important roles affected in many optic neurodegenerative diseases like glaucoma. Among the genetic risks associated with glaucoma, the E50K mutation in the Optineurin (OPTN) gene are known to result in glaucoma in the absence of increased intraocular pressure (IOP), whereas...

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Identifiers

PMID: 35436991
DOI: 10.1038/s41419-022-04836-3
PMCID: PMC9016082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.PMID 35436991Read ↗

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