Article
Visual impairment in an optineurin mouse model of primary open-angle glaucoma.
Neurobiology of aging - 1 Jun 2015
Tseng Henry C, Riday Thorfinn T, McKee Celia, Braine Catherine E, Bomze Howard, Barak Ian, Marean-Reardon Carrie, John Simon W M, Philpot Benjamin D, Ehlers Michael D
Abstract excerpt
Primary open-angle glaucoma (POAG) is characterized by progressive neurodegeneration of retinal ganglion cells (RGCs). Why RGCs degenerate in low-pressure POAG remains poorly understood. To gain mechanistic insights, we developed a novel mouse model based on a mutation in human optineurin associated with hereditary, low-pressure POAG. This mouse improves the design and phenotype of currently available optineurin...
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