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Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration

2025-02-15

Abstract excerpt

Progressive loss of retinal ganglion cells (RGCs) and degeneration of optic nerve axons are the pathological hallmarks of glaucoma. Ocular hypertension (OHT) and mitochondrial dysfunction are linked to neurodegeneration and vision loss in glaucoma. However, the exact mechanism of mitochondrial dysfunction leading to glaucomatous neurodegeneration is poorly understood. Using multiple mouse models of OHT and human e...

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Identifiers and source

Literature Corpus work
0018a076-8297-5f5f-aa6c-23082638577c
DOI
10.1101/2025.02.13.638142
Open publication

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Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegenerationDOI 10.1101/2025.02.13.638142
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