Article
Glaucoma-associated Optineurin mutations increase transcellular degradation of mitochondria in a vertebrate optic nerve.
eLife - 12 Aug 2025
Jeong Yaeram, Davis Chung-Ha O, Muscarella Aaron M, Navarro Hector H, Deshpande Viraj, Moore Lucy G, Kim Keun-Young, Ellisman Mark H, Marsh-Armstrong Nicholas
Abstract excerpt
We previously described a process whereby mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large-effect glaucoma genes and axonal damage occurs at the optic nerve head in glaucoma, here we explored whether OPTN mutations perturb the transcellular degradation...
Topics
Join the communities discussing this publication.