Article

Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve

2023-05-30

Abstract excerpt

We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large- effect glaucoma genes and axonal damage occurs at the optic nerve head in glaucoma, here we explored whether OPTN mutations perturb t...

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Literature Corpus work: 82142e80-5b4c-5a10-b901-73cdea41329a
DOI: 10.1101/2023.05.26.542507

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