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Article

Genome-wide polygenic risk impact on intracranial aneurysms and acute ischemic stroke.

PloS one - 1 Jan 2022

Hong Eun Pyo, Youn Dong Hyuk, Kim Bong Jun, Lee Jae Jun, Na Doyoung, Ahn Jun Hyong, Park Jeong Jin, Rhim Jong Kook, Kim Heung Cheol, Jeon Hong Jun, Hwang Gyojun, Jeon Jin Pyeong

Abstract excerpt

Polygenic risk scores (PRSs) have an important relevance to approaches for clinical usage in intracranial aneurysm (IA) patients. Hence, we aimed to develop IA-predicting PRS models including the genetic basis shared with acute ischemic stroke (AIS) in Korean populations. We applied a weighted PRS (wPRS) model based on a previous genome-wide association study (GWAS) of 250 IA patients in a hospital-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35427368
DOI: 10.1371/journal.pone.0265581
PMCID: PMC9012378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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