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Genome-Wide Association Study and Fine Mapping Uncover Key Genetic Loci and Credible Genes of Intracranial Aneurysm and Aneurysmal Subarachnoid Hemorrhage.

Stroke - 1 Jul 2026

Maimaiti Aierpati, Jia Ningning, Feng Yu, Ji Xiaolong, He Chenxi, Turhon Mirzat, Aisha Maimaitili, Shen Jing, Yang Sheng, Wang Yongxin, Wang Zengliang

Abstract excerpt

BACKGROUND: Intracranial aneurysm (IA) is a common neurovascular disorder; rupture causes aneurysmal subarachnoid hemorrhage with high mortality. Despite available interventions, effective preventative therapies are lacking. We aimed to identify novel genetic determinants of IA and aneurysmal subarachnoid hemorrhage to improve risk prediction and nominate hypothesis-generating therapeutic candidates for future...

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PMID: 42200286
DOI: 10.1161/STROKEAHA.126.055253

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GPX1
NPC1

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