Article
Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.
Journal of the American Heart Association - 14 Jul 2016
van 't Hof Femke N G, Ruigrok Ynte M, Lee Cue Hyunkyu, Ripke Stephan, Anderson Graig, de Andrade Mariza, Baas Annette F, Blankensteijn Jan D, Böttinger Erwin P, Bown Matthew J, Broderick Joseph, Bijlenga Philippe, Carrell David S, Crawford Dana C, Crosslin David R, Ebeling Christian, Eriksson Johan G, Fornage Myriam, Foroud Tatiana, von Und Zu Fraunberg Mikael, Friedrich Christoph M, Gaál Emília I, Gottesman Omri, Guo Dong-Chuan, Harrison Seamus C, Hernesniemi Juha, Hofman Albert, Inoue Ituro, Jääskeläinen Juha E, Jones Gregory T, Kiemeney Lambertus A L M, Kivisaari Riku, Ko Nerissa, Koskinen Seppo, Kubo Michiaki, Kullo Iftikhar J, Kuivaniemi Helena, Kurki Mitja I, Laakso Aki, Lai Dongbing, Leal Suzanne M, Lehto Hanna, LeMaire Scott A, Low Siew-Kee, Malinowski Jennifer, McCarty Catherine A, Milewicz Dianna M, Mosley Thomas H, Nakamura Yusuke, Nakaoka Hirofumi, Niemelä Mika, Pacheco Jennifer, Peissig Peggy L, Pera Joanna, Rasmussen-Torvik Laura, Ritchie Marylyn D, Rivadeneira Fernando, van Rij Andre M, Santos-Cortez Regie Lyn P, Saratzis Athanasios, Slowik Agnieszka, Takahashi Atsushi, Tromp Gerard, Uitterlinden André G, Verma Shefali S, Vermeulen Sita H, Wang Gao T, Han Buhm, Rinkel Gabriël J E, de Bakker Paul I W
Abstract excerpt
BACKGROUND: Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND RESULTS: We performed a mega-analysis of 1000 Genomes Project-imputed genome-wide association study (GWAS) data of 4...
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