Article
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
Nature genetics - 1 Dec 2020
Bakker Mark K, van der Spek Rick A A, van Rheenen Wouter, Morel Sandrine, Bourcier Romain, Hostettler Isabel C, Alg Varinder S, van Eijk Kristel R, Koido Masaru, Akiyama Masato, Terao Chikashi, Matsuda Koichi, Walters Robin G, Lin Kuang, Li Liming, Millwood Iona Y, Chen Zhengming, Rouleau Guy A, Zhou Sirui, Rannikmäe Kristiina, Sudlow Cathie L M, Houlden Henry, van den Berg Leonard H, Dina Christian, Naggara Olivier, Gentric Jean-Christophe, Shotar Eimad, Eugène François, Desal Hubert, Winsvold Bendik S, Børte Sigrid, Johnsen Marianne Bakke, Brumpton Ben M, Sandvei Marie Søfteland, Willer Cristen J, Hveem Kristian, Zwart John-Anker, Verschuren W M Monique, Friedrich Christoph M, Hirsch Sven, Schilling Sabine, Dauvillier Jérôme, Martin Olivier, Jones Gregory T, Bown Matthew J, Ko Nerissa U, Kim Helen, Coleman Jonathan R I, Breen Gerome, Zaroff Jonathan G, Klijn Catharina J M, Malik Rainer, Dichgans Martin, Sargurupremraj Muralidharan, Tatlisumak Turgut, Amouyel Philippe, Debette Stéphanie, Rinkel Gabriel J E, Worrall Bradford B, Pera Joanna, Slowik Agnieszka, Gaál-Paavola Emília I, Niemelä Mika, Jääskeläinen Juha E, von Und Zu Fraunberg Mikael, Lindgren Antti, Broderick Joseph P, Werring David J, Woo Daniel, Redon Richard, Bijlenga Philippe, Kamatani Yoichiro, Veldink Jan H, Ruigrok Ynte M
Abstract excerpt
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over...
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