Article
Susceptibility loci for intracranial aneurysm in European and Japanese populations.
Nature genetics - 1 Dec 2008
Bilguvar Kaya, Yasuno Katsuhito, Niemelä Mika, Ruigrok Ynte M, von Und Zu Fraunberg Mikael, van Duijn Cornelia M, van den Berg Leonard H, Mane Shrikant, Mason Christopher E, Choi Murim, Gaál Emília, Bayri Yasar, Kolb Luis, Arlier Zulfikar, Ravuri Sudhakar, Ronkainen Antti, Tajima Atsushi, Laakso Aki, Hata Akira, Kasuya Hidetoshi, Koivisto Timo, Rinne Jaakko, Ohman Juha, Breteler Monique M B, Wijmenga Cisca, State Matthew W, Rinkel Gabriel J E, Hernesniemi Juha, Jääskeläinen Juha E, Palotie Aarno, Inoue Ituro, Lifton Richard P, Günel Murat
Abstract excerpt
Stroke is the world's third leading cause of death. One cause of stroke, intracranial aneurysm, affects approximately 2% of the population and accounts for 500,000 hemorrhagic strokes annually in mid-life (median age 50), most often resulting in death or severe neurological impairment. The pathogenesis of intracranial aneurysm is unknown, and because catastrophic hemorrhage is commonly the first sign of disease,...
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