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Article

The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)-Warfarin.

Clinical pharmacology and therapeutics - 1 Jul 2022

Wanounou Maor, Shaul Chanan, Abu Ghosh Zahi, Alamia Shoshana, Caraco Yoseph

Abstract excerpt

Cytochrome P450 2C9 (CYP2C9) is responsible for the oxidative metabolism of about 15% of commonly used drugs, some of which are characterized by a narrow therapeutic window. CYP2C9 is highly polymorphic, and over 60 alleles have been described. CYP2C9*2 and CYP2C9*3 are the most common polymorphisms among White patients and both are associated with decreased activity. The evidence concerning the functional...

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Identifiers

PMID: 35426132
DOI: 10.1002/cpt.2613
PMCID: PMC9322346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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