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Article

Clinical relevance of genetic polymorphisms in the human <i>CYP2C9</i> gene

20 Oct 2003

Abstract excerpt

Cytochrome p450 (CYP) 2C9 hydroxylates about 16% of drugs in current clinical use. Of special interest are those with a narrow therapeutic index, such as S-warfarin, tolbutamide and phenytoin, where impairment in CYP2C9 metabolic activity might cause difficulties in dose adjustment as well as toxicity. Single-nucleotide polymorphisms (SNP) in the CYP2C9 gene have increasingly been recognized as determinants of...

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PMID: 14641553
DOI: 10.1046/j.1365-2362.33.s2.6.x

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